Role of Oxidative Stress, ER Stress and Ubiquitin Proteasome System in Neurodegeneration

NDD: Neurodegenerative Disorders; ER: Endoplasmic Reticulum; UPS: Ubiquitin Proteasome System; ROS: Reactive Oxygen Species; AD: Alzheimer’s Disease; PD: Parkinson’s Disease; MS: Multiple Sclerosis; HD: Huntington’s Disease; ALS: Amyotrophic Lateral Sclerosis; PS: Presenilin; APP: Amyloid beta (A4) Precursor Protein; MARK1: Microtubule Affinity-Regulating Kinase 1; SOD-1: Superoxide Dismutase 1; VAMP : VesicleAssociated Membrane Protein; ALS2: Amyotrophic Lateral Sclerosis 2; DCTN1: Dynactin 1; FUS : FUS RNA binding protein; TDP43: TAR DNA binding Protein; PERK: Phosphorylation of the ER stress Kinases; IRE 1: Inositol-Requiring Enzyme 1; SCA: Spinocerebellar Ataxia; GSK: Glycogen Synthase Kinase; ASK1: Apoptosis Signal-Regulating Kinase 1; JNK: c-Jun NH2-terminal kinase; Keap1: Kelch-like ECH-associated protein 1; MGRN1: Mahogunin Ring finger 1, E3 ubiquitin protein ligase; MYCBP2: MYC Binding Protein 2, E3 ubiquitin protein ligase; UHRF2: Ubiquitin-like with PHD and Ring Finger domains 2; ZNRF1: Zinc and Ring Finger 1, E3 ubiquitin protein ligase; NEDD4: Neural precursor cell Expressed, Developmentally Down-regulated 4, E3 ubiquitin protein ligase; NEDD4L: Neural precursor cell Expressed, Developmentally Down-regulated 4-like, E3 ubiquitin protein Ligase; HECTD2: HECT domain containing E3 ubiquitin protein ligase 2; PJA2: Praja ring finger 2, E3 ubiquitin protein ligase; RNF19: Ring finger protein 19A, RBR E3 ubiquitin protein ligase; HECTD1: HECT domain containing E3 ubiquitin protein ligase 1; MULAN: Mitochondrial E3 Ubiquitin protein Ligase 1; HACE1: HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1; TRIM13: Tripartite Motif containing 13; AIMP2: Aminoacyl tRNA synthetase complex-Interacting Role of Oxidative Stress, ER Stress and Ubiquitin Proteasome System in Neurodegeneration